Hi Miss Frankie,
I actually had a conversation with a 3rd party auditor about this recently. Our facility runs Mon-Fri and I typically come in Sunday evening to do environmental swabs (because we start very early on Monday, so it avoids conflicts with production's startup). He said there is technically no issue with doing zone 1 swabs after the weekend, but you need to consider 1) if the equipment is not fully cleaned, the longer it sits before testing, the higher your results will be and 2) dust/other particulate settling over the weekend and re-contaminating the surfaces. As for zones 2-4, I was told they should always be done during production.
This was the advice of one auditor, but I don't believe there is any specific rule about it. We do it at this facility and it has never been an issue, but of course you should assess it yourself. When we made the switch from swabbing late Friday night to Sunday night we did it for 2 months and compared our results to previous results and found no significant difference, so I would suggest trying it out.
Hope this helps!