Hi,
We produce a dry powder with a very low microbiological risk. One (commercial) lotnumber can contain about 10.000kgs of product. It takes about 25 "runs" to produce this 10.000 kgs and we now take retention samples (bags) every run. As the shelf life is 3 years, I now have a massive archive with samples which we barely use (as there have no chemical or microbiological problems appeared so far).
How can I determine the best frequency of sampling? It feels kind of safe to have this amount of samples (if there would be a problem we can narrow it down to one specific run), but it seems to me a little overdone also...